Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer) Clinical Trial
Official title:
A Multicenter, Non-Randomized, Phase II Study of Regorafenib for Advanced Urothelial Cancer Following Prior Chemotherapy
This study will test how well Regorafenib controls disease progression in urothelial cancer (cancer occurring in the urinary bladder, ureters, or renal pelvis) following previous therapy with chemotherapy.
Advanced urothelial carcinoma (UC) has a poor long-term prognosis. The disease has not seen
improved outcomes despite research efforts in over two decades. Novel therapeutic options are
needed. Regorafenib is a novel oral multikinase inhibitor but is more potent than a similar
multikinase inhibitor drug that treats advanced renal cell carcinoma and hepatocellular
carcinoma. Regorafenib has been shown to have a broader capacity to inhibit blood supply to
tumor sources.
This trial evaluates a proof-of-concept using Regorafenib in patients with metastatic
progressive urothelial carcinoma following chemotherapy but still have a high level of
activity performance in their daily living. The initial dose of Regorafenib will be 120 mg
daily and then be escalated to 160 mg daily before gradually tapering.
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