Detection of Chlamydia DNA by Polymerase Chain Reaction in Primary Tubal and Ovarian Cancers Tissues : a Pilot Study

Malignant Neoplasm of Fallopian Tube Clinical Trial

Official title:

Detection of Chlamydia DNA by Polymerase Chain Reaction ( PCR ) in Tumours Tissue of Primary Tubal and Ovarian Cancers : a Pilot Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02343510
• Other study ID #: lab7682
• Status: Completed
• Phase: N/A
• First received: January 10, 2015
• Last updated: July 16, 2017
• Start date: January 2015
• Est. completion date: March 2017

Study information

• Verified date: July 2017
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

PCR for chlamydia DNA is done in paraffin blocks of cases of primary tubal cancer and is compared to cases of high grade serous ovarian cancer and normal tubes .

Description:

The investigators shall review the early cancer detection unite pathology records for the past 10 years , for cases diagnosed with primary Fallopian tube cancers , cases of high and low grade serous ovarian cancer and cases underwent hysterectomy and salpingectomy for non oncological reasons. Paraffin blocks for suitable selected patients will be examined histologically to confirm the primary diagnosis . Chlamydia DNA in these paraffin blocks of the Fallopian tubes and ovarian tissues will be examined using PCR techniques . The possible correlation between the presence of Chlamydia DNA and the ovarian serous tumours and primary tubal cancer will be analyzed statistically .

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: March 2017
• Est. primary completion date: March 2017
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

• any patient with primary tubal cancer and high grade serous cancer and normal tubes.

Exclusion Criteria:

• clinical pelvic inflammatory disease

• salpingectomy for ectopic

Related Conditions & MeSH terms

• Fallopian Tube Neoplasms
• Malignant Neoplasm of Fallopian Tube
• Neoplasms
• Ovarian Neoplasms

Intervention

Other:
• PCR for chlamydia DNA in primary tubal cancer
PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups

Locations

Country	Name	City	State
Egypt	Ain Shams Maternity Hospital	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Presence of chlamydia DNA in tubal and ovarian tissues		Up to 24 weeks
Secondary	Presence of concomitant tubal cancer with high grade serous ovarian cancer		Up to 8 weeks