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The Effects of PXR Activation on Hepatic Fat Content

Non-alcoholic Fatty Liver Disease Clinical Trial

Official title:
PXR-aktivaation Vaikutus Maksan Rasvoittumiseen

Clinical Trial Summary

This study investigates the effects of pregnane X receptor (PXR) activation on hepatic fat content in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers. Hepatic fat content is measured with magnetic resonance imaging and blood samples are collected at the end of each study arm. The investigators' hypothesis is that rifampicin causes accumulation of fat to the liver.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02329405
Study type Interventional
Source University of Oulu
Contact
Status Completed
Phase Phase 4
Start date December 2014
Completion date January 2017
View Details
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