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Clinical Implications of DNA Analysis on ADPKD — DNAAA  

Autosomal Dominant Polycystic Kidney Disease Clinical Trial

Official title:
Mutational Types and Phenotypes Relationship in Autosomal Dominant Polycystic Kidney Disease

Clinical Trial Summary

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease. We plan DNA analysis using the next generation sequencer (NGS) and examine the relationship between mutational types and clinical phenotypes. The accuracy of DNA analysis with NGS is tested by Sanger's method. The kidney and life survival curves will be compared between PKD1, PKD2 and non-ADPKD family members.

Clinical Trial Description

80 unrelated patients with ADPKD attending to the Kyorin University Hospital whose clinical data are compiled. DNA analysis is performed at Otsuka Pharmaceutical Laboratory.

Clinical data include total kidney volume (TKV), TKV slope, eGFR, eGFR slope and other clinically relevant data. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02322385
Study type Observational
Source Kyorin University
Contact
Status Completed
Phase N/A
Start date January 2014
Completion date December 31, 2016
View Details
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