Severe Pre-eclampsia With Postnatal Complication Clinical Trial
Official title:
A Novel Protocol for Postpartum Magnesium Sulfate in Severe Preeclampsia When the Woman Received Less That 8 Hours Before Delivery. Six Versus Twenty-four Hours Postpartum
There are huge doubts as to how long to keep postpartum magnesium sulfate. Studies demonstrating the usefulness for 24, 12 or 6 hours are of little evidence and do not take into account the use of magnesium sulphate before delivery. Termination of pregnancy is the best option to prevent eclampsia and magnesium sulphate has proven effective, but do not know the minimum effective dose.The investigators believe that if the patient has received less than 8 continuous hours of magnesium sulphate before delivery, maintain magnesium sulfate for 6 hours is as effective as keeping it for 24 hours.
The definitive treatment known for pre-eclampsia is the interruption of pregnancy. While the
definitive treatment is the pregnancy interruption, management includes other measures that
have proven effective, including the administration of antihypertensive drugs for severe
hypertension and that the use of anticonvulsant such as the magnesium sulfate.
There are multiple studies that prove the effectiveness of magnesium sulfate to prevent
eclampsia in patients with severe / serious disorder. Unfortunately these studies used the
drug before birth and continue after birth. Therefore the investigators can not conclude
whether the administration just before pregnancy is sufficient to prevent seizure. That is,
if the cure or definitive treatment of pre-eclampsia is the interruption, did not seem
necessary to justify the administration of anticonvulsant drugs after birth. Obvious post
delivery management sulfate arises from the large number of postpartum eclampsia reported in
many studies. It is unknown if the administration of magnesium sulfate for a minimum period
not yet determined before birth and delivery requires even keep the drug after
discontinuation.
For all these reasons the investigators propose the following: A randomized trial where all
those patients who received magnesium sulfate for less that 8 hours before birth will be
randomized to two groups of study: 1- Continue magnesium sulfate for 24 hours and 2-Continue
magnesium sulfate for 6 hours postpartum.
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