Systemic Inflammatory Response Syndrome Clinical Trial
Official title:
The Prevention and Treatment of SIRS in Patients With Cholestatic Jaundice After Operation.
RATIONALE:Anticholinesterase drugs and cholinergic M receptor antagonist are applied to
patients who have obstructive jaundice after operation.
PURPOSE:This clinical trial was designed to lower the incidence and mortality of operation
complications in patients with obstructive jaundice .
OBJECTIVES:
Ⅰ.Judge whether it has the effect of inhibiting inflammation, anti oxidative stress and anti
apoptosis when the alpha 7 nicotinic acetylcholine receptors are activated .
Ⅱ.Judge whether it has the effect of reducing the incidence and mortality of operation
complication when using Cholinesterase inhibitors and M cholinergic receptor blocking agent
in Patients with obstructive jaundice after operation。
OUTLINE:Patients are assigned to 1 of 2 groups according to order of enrollment.
Group 1:Patients receive neostigmine methylsulfate and raceanisodamine hydrochloride on days
0,1,2 after operation.
Group 2:Patients do not receive any special treatment after operation.
All patients should be monitored the observed indexes on the day before the operation and
one day, three days, five days after the operation.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02518087 -
Increased Adsorption Membranes During Cardiopulmonary Bypass
|
N/A | |
| Completed |
NCT02902939 -
Myeloid-Derived Supressor Cells in Cardiac Surgery Patients
|
N/A | |
| Completed |
NCT02563652 -
Can Biomarkers Aid in the Prediction of Postoperative Pain and Circulatory Instability After Major Abdominal Surgery?
|
||
| Recruiting |
NCT01157299 -
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
|
N/A | |
| Completed |
NCT01388725 -
Comparison the Value of Several Biomarkers of Sepsis
|
N/A | |
| Unknown status |
NCT00254176 -
Cysteine Supplementation in Critically Ill Neonates
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT03617796 -
Prognostic Value of CD64 Marker for Patients in Intensive Care Unit
|
||
| Completed |
NCT03876041 -
Evaluation of Corticosteroid in Systemic Inflammatory Response Syndrome
|
Phase 4 | |
| Recruiting |
NCT05608096 -
European Registry for Hemadsorption in Sepsis With the Seraph Filter
|
||
| Completed |
NCT03314831 -
The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Sepsis
|
||
| Completed |
NCT02568410 -
Platelets as Regulators of Inflammation in Cardiac Surgery
|
||
| Completed |
NCT01636232 -
Vitamin D and Critically Ill Patients
|
N/A | |
| Completed |
NCT01020409 -
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
|
Phase 4 | |
| Completed |
NCT04624776 -
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
|
Phase 2 | |
| Recruiting |
NCT05172739 -
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
|
Phase 4 | |
| Recruiting |
NCT02957175 -
Immunophenotyping of Patients With Postoperative SIRS
|
||
| Completed |
NCT02320539 -
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
|
N/A | |
| Completed |
NCT01708759 -
IL8 Monitoring and Its Correlation With 251-gene Polymorphism
|
N/A | |
| Terminated |
NCT00708799 -
Efficacy of Macrolide Immunomodulation in Severe Sepsis.
|
Phase 2 | |
| Recruiting |
NCT04580680 -
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
|