Breaking Prolonged Sitting With Physical Activity Clinical Trial
Great controversy exists with respect to the optimal or the minimum volume, intensity, and
frequency of physical activity capable of attenuating the hazards of prolonged sitting on
the metabolic profile. Thus, our study aims to comprehensively investigate the effects of
disrupting prolonged sitting with different physical activity protocols on metabolic risk
factors in sedentary males.
Ten sedentary males will take part in this randomized cross-over trial consisting of four
27-h conditions. All conditions will be identical except for the physical activity:
prolonged sitting intervention (SIT) participants will sit continuously for 9 hours;
prolonged sitting+interval standing intervention (STAND), participants will stand for 15 min
every 30 minutes (total 270 min) during the 9 hours of sitting; prolonged
sitting+moderate-intensity exercise bout (MVPA) participants will perform a 30-min
moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they
will sit for the remaining time; and prolonged sitting+moderate-intensity exercise bout
+interval standing intervention (MVPA-STAND), participants will perform a 30-min
moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they
will stand for 15 min every 30 minutes (total 240 min) during the remaining 8 hours of
sitting. Blood glucose, insulin, lipids and cytokines will be determined.
The investigators expect that disrupting prolonged sitting with intermittent standing and a
moderate-exercise bout will positively affect the metabolic profile of the participants.
Furthermore, we will investigate if combined, these strategies will have an additive effect.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment