Verticality Perception - Multisensory Contribution

Individual Contribution of Different Sensory Systems Clinical Trial

Official title:

Verticality Perception - Dissociating Head and Trunk Contributors in Healthy Human Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02212704
• Other study ID #: perception_head_roll_zurich
• Status: Completed
• Phase: N/A
• First received: August 6, 2014
• Last updated: December 1, 2015
• Start date: October 2014
• Est. completion date: November 2015

Study information

• Verified date: December 2015
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: November 2015
• Est. primary completion date: November 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• ages 18-60 years

• informed consent

• absence of exclusion criteria

Exclusion Criteria:

• peripheral-vestibular deficit

• disturbed consciousness

• history of sensory deficits

• visual field deficits

• other neurological or systemic disorder which can cause dementia or cognitive dysfunction

• intake of antidepressants, sedatives, or neuroleptics

• pregnancy, unless excluded by a negative pregnancy test

• known neck pain or status post neck trauma

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Individual Contribution of Different Sensory Systems
• Verticality Perception in Healthy Human Subjects

Intervention

Other:
• Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)

• 3D-video-head impulse testing
Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study
• Vestibular-evoked myogenic potentials (VEMPs)
Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich, Dept. of Neurology	Zurich	ZH

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions		During the turntable measurement (90 minutes)	No
Secondary	relative contribution of head- and trunk-based sensory systems based on Bayesian modelling		while on the turntable (1.5 hours)	No