Attention Deficit/Hyperactivity Disorder Clinical Trial
— ADHDNTxOfficial title:
A Pilot Study of Near Infrared Spectroscopy Neurofeedback Training of Prefrontal Cortex in Attention Deficit Hyperactivity Disorder
NCT number | NCT02205268 |
Other study ID # | NEPADHDNTX |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | July 29, 2014 |
Last updated | October 13, 2015 |
Start date | March 2013 |
Background Attention Deficit Hyperactivity Disorder (ADHD) is one of the most frequently
diagnosed behavioural disorders in childhood that requires treatment(3-5% of children). It
is an important health problem because it impairs social, educational and occupational
performance, and increases the risk of other psychiatric disorders including anxiety,
depression and substance misuse. There is no cure for ADHD and standard stimulant medication
treatment is at best symptomatic. Moreover, stimulants have side effects and parents are
often concerned over the long-term effects. A number of non-drug treatments have been
developed but these do not target the brain directly. Neurofeedback Training (NTx) is a new,
non-drug treatment that targets the brain directly and that can potentially enhance the
control of attention in ADHD. NTx could be a valuable alternative and/or adjunct to standard
care.
Aims Although NTx has gained popularity in Europe and the US, more rigorous studies are
required to support its implementation in the NHS. We therefore propose a pilot study to
establish tolerabilty and safety, and to develop treatment protocols and collect data to
design a follow-on controlled NTx trial in ADHD.
Methods We plan an open label, single arm, treatment trial of near infrared spectroscopy
neurofeedback training of frontal lobe activation in school-aged children with ADHD. 48
participants will be recruited over 1 year and will be offered 20 NTx sessions over 10
weeks. Participants will be recruited from Mental Health Services. Primary outcomes will be
safety and tolerability and secondary outcomes will include standard clinical behavioural
rating scales and the Test Of the Variables of Attention.
Status | Recruiting |
Enrollment | 48 |
Est. completion date | |
Est. primary completion date | March 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 7 Years to 17 Years |
Eligibility |
Inclusion Criteria: - Patients diagnosed with ADHD aged 7 to 17 years - Patient and legal guardian able to communicate in English - Patient has been living with parent/guardian for at least six months - Patient attending school for at least 2 days / week - ADHD as primary disorder with symptoms present for at least 9 months - Participants on medication treatment for ADHD must have been on a stable dose for 3 months prior to commencement of the treatment Exclusion Criteria: - Significant visual or hearing impairment that would preclude use of NIRS- neurofeedback - Global learning disability, Autism, psychosis, bipolar disorder, depression, suicidal ideation, or another psychiatric disorder requiring treatment with additional psychotropic medication, current substance dependance or regular use, and severe sleep disorders |
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United Kingdom | Aylmer House | Harlow | Essex |
Lead Sponsor | Collaborator |
---|---|
North Essex Partnership NHS Foundation Trust | Hertfordshire Community NHS Trust, University College, London |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Recruitment and retention rates | The primary outcome measure is the percentage of participants who complete 75% of the 20 training sessions offered. | 10 weeks | No |
Secondary | Adverse effects | Occurrence and frequency of training related adverse effects. | 10 weeks | No |
Secondary | Attentional and impulsivity measures | Test of Variables of attention (TOVA) | 10 weeks | No |
Secondary | Problem behaviour measure | Childhood behavioural checklist (CBCL) | 10 weeks | No |
Secondary | Diagnostic and severity measure | Swanson, Nolan and Pelham Questionnaire version IV (SNAPIV) | 10 weeks | No |
Secondary | Psychiatric and social function measure | Children's Global Assessment Scale. The CGAS is an adaptation of the Global Assessment Scale (GAS) for young people aged 4-16 years | 10 weeks | No |
Secondary | Treatment response assessment | CGI (Clinical Global Impression) is a three-item scale used to assess treatment response in psychiatric patients | 10 weeks | No |
Secondary | Study satisfaction questionnaire | Measure of satisfaction of participating. | 10 weeks | No |
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