Avascular Necrosis of Femoral Head Clinical Trial
Official title:
The Effect of Tranexamic Acid on Blood Coagulation After Colloid Infusion During Surgery: Rotational Thromboelastography Measurement
Colloid solution is generally used to maintain intravascular volume. It is reported to
impair blood coagulation in vivo and in vitro more than crystalloid does by prolonging
coagulation time and decreasing clot strength. The formed fibrin clot is more vulnerable for
fibrinolysis in a case of using colloid. Dilution of plasmin in vitro with colloid enhances
fibrinolysis primarily by diminishing α2-antiplasmin-plasmin interaction.
Tranexamic acid is an antifibrinolytics that competitively inhibits the activation of
plasminogen, by binding to specific site of both plasminogen and plasmin, a molecule
responsible for the degradation of fibrin, a protein that forms the framework of blood clot.
It is used to treat or prevent excessive blood loss during surgery and in other medical
conditions. Gastrointestinal effect, dizziness, fatigue, headache, hypersensitivity
reaction, or potential risk of thrombosis is reported as the adverse effect of tranexamic
acid.
We hypothesized that inhibition of plasmin by tranexamic acid after colloid administration
can improve the colloid-induced clot strength impairment.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04941729 -
Study to Evaluate the Safety and Efficacy of OR3O™ Dual Mobility System vs. Conventional Single Bearing Design Total Hip System
|
N/A | |
| Completed |
NCT00939900 -
Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head
|
Phase 3 |