Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

Loculated or Non-draining Malignant Pleural Effusions Clinical Trial

Status Recruiting

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy and safety of intrapleural dornase alfa and tPA administered to patients with clinical failure of small-bore chest tube with persistent pleural effusions or malignancy-related loculated effusion to improve pleural drainage.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Loculated or Non-draining Malignant Pleural Effusions
• Pleural Effusion
• Pleural Effusion, Malignant

• NCT number: NCT02135588
• Study type: Interventional
• Source: Eastern Regional Medical Center
• Contact: Steven B Standiford, MD
• Phone: 215-537-7400
• Email: steven.standiford@ctca-hope.com
• Status: Recruiting
• Phase: Phase 1
• Start date: October 2013
• Completion date: December 2021