Corneal Opacities (Scar and Stromal Dystrophy) Clinical Trial
Official title:
Observational Study of Corneal Opacities in Adults
A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imaging, will be performed for comparison.
| Status | Recruiting |
| Enrollment | 150 |
| Est. completion date | December 2025 |
| Est. primary completion date | December 2025 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years to 100 Years |
| Eligibility | Inclusion Criteria: • Adult (18 & older) patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy) Exclusion Criteria: - Inability to give informed consent. - Inability to maintain stable fixation for OCT imaging. - Inability to commit to required visits to complete the study. |
| Country | Name | City | State |
|---|---|---|---|
| United States | Humberto Martinez | Portland | Oregon |
| Lead Sponsor | Collaborator |
|---|---|
| Oregon Health and Science University | National Eye Institute (NEI) |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Identification of suitable subjects | The primary goal of this observational study is to identify suitable subjects for the clinical trials of OCT-guided transepithelial PTK. | 2 years | |
| Secondary | Validate OCT topography | A second goal is to validate OCT anterior topography by comparison with standard Placido-ring corneal topography and develop a mathematical model that relates epithelial thickness variation to corneal mean curvature. | 2 years |