Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02108093

The Effect on Cerebral Oxygenation of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit in Cardiac Surgery Patients — RAP  

Postoperative Cognitive Dysfunction Clinical Trial

Official title:
The Effect on Cerebral Oxygenation of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit in Cardiac Surgery Patients: a Randomized Controlled Trial

Clinical Trial Summary

The effect of retrograde autologous priming (RAP) on regional cerebral oxygenation (rSO2) still remains unclear, because studies are limited in sample size and study design, and because of the absence of prospective studies. The investigators hypothesize that RAP limits the degree of hemodilution and thereby limits prolonged intraoperative cerebral desaturation during cardiopulmonary bypass (CPB), compared to the conventional priming method.

The primary objective of this study is to determine whether RAP limits the degree of hemodilution and limits prolonged intraoperative cerebral desaturation during cardiopulmonary bypass, compared to the conventional priming method. Prolonged intraoperative cerebral desaturation will be assessed by rSO2 desaturation score50. rSO2 desaturation score50 > 3000 is associated with increased risk of cognitive decline. The investigators hypothesize that RAP limits the degree of hemodilution and thereby limits the incidence of rSO2 desaturation score50 > 3000 with a relative difference of 50%.

The subjects who are divided in the RAP group, the retrograde autologous priming technique will be used, where the patient's own circulating blood partially will be replaced by the priming solution in the cardiopulmonary bypass. In the Control group the conventional priming method will be used. The main study parameters is rSO2 desaturation score50.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02108093
Study type Interventional
Source Amphia Hospital
Contact Dorien Kimenai, Bsc
Email dkimenai@amphia.nl
Status Recruiting
Phase N/A
Start date December 2014
Completion date December 2015
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05990790 - The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium Phase 4
Terminated NCT03337282 - Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
Active, not recruiting NCT02965235 - Correlations of Epigenetic Changes With POCD in Surgical Patients N/A
Not yet recruiting NCT02224443 - Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients Phase 4
Recruiting NCT01934049 - Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Phase 4
Terminated NCT00991328 - Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery Phase 3
Terminated NCT00757913 - n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery Phase 4
Terminated NCT00455143 - Cognitive Protection - Dexmedetomidine and Cognitive Reserve Phase 4
Recruiting NCT06176144 - Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients N/A
Completed NCT03620968 - Implementation of a Cognitive Training Program to Reduce the Risk of Postoperative Cognitive Dysfunction N/A
Completed NCT04701801 - Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients
Not yet recruiting NCT06469515 - Older People's Neurocognitive Recovery After Cardiac Surgery
Completed NCT02931877 - Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia Phase 4
Not yet recruiting NCT02909413 - Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function N/A
Completed NCT02650687 - Optimizing Postoperative Cognition the Elderly
Not yet recruiting NCT01622452 - Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques N/A
Completed NCT01103752 - Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up N/A
Completed NCT04312516 - Greek Validation of ACE III Test in Perioperative Patients
Not yet recruiting NCT05668559 - Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders N/A
Not yet recruiting NCT05439707 - Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP N/A