Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults

Transcutaneous Electrical Nerve Stimulation Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02077595
• Other study ID #: 101-3624B
• Status: Completed
• Phase: N/A
• First received: February 11, 2014
• Last updated: March 3, 2014
• Start date: January 2013
• Est. completion date: July 2013

Study information

• Verified date: March 2014
• Source: Chang Gung University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Interventional

Clinical Trial Summary

Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: July 2013
• Est. primary completion date: July 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• Healthy adults

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Transcutaneous Electrical Nerve Stimulation

Intervention

Device:
• transcutaneous electrical nerve stimulation, TENS
Then participants will receive stimulation for 20 minutes.

Locations

Country	Name	City	State
Taiwan	Chang Gung University	Taoyuan

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Motor evoked potential	measure of intracortical inhibition on abductor pollicis brevis by single-pulse TMS.	Baseline	Yes
Primary	Intracortical inhibition, ICI	Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.	Baseline,2 hours, 2.5 hours,and 3 hours	Yes
Primary	intracortical facilitation, ICF	Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.	Baseline,Baseline,2 hours, 2.5 hours,and 3 hours	Yes