Anesthesia Intubation Complication Clinical Trial
Official title:
The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery
Sore throat is one of most frequent complaints related to general anesthesia with tracheal
intubation. Although sore throat is regarded as a minor and short-lasting discomfort after
surgery, its incidence and intensity in high risk patients such as female gender, head and
neck surgery and difficult laryngoscopy or intubation may attribute to prolong postoperative
recovery and give patient dissatisfaction.
Even though the pathophysiology of post-intubation airway symptoms is not completely
clarified yet, the mucosal damage related inflammation at the cuff of endotracheal tube has
been thought to be an essential trigger. Thus anti-inflammatory medication has been commonly
used strategy to prevent postoperative airway discomfort after intubation. The preoperative
administration of dexamethasone has been reported to reduce the incidence and severity of
postoperative sore throat, but it is accompanied with the adverse effects such as
hyperglycemia, delayed wound healing and increased infection in surgical patients.
Ketorolac, non-steroidal anti-inflammatory drug (NSAID), is an analgesic that commonly used
for postoperative pain control and has anti-inflammatory effect.
Therefore, the investigator designed to evaluate the effect of ketorolac on sore throat in
comparison to dexamethasone after thyroidectomy in female adult patients
Ketorolac, NSAID, has not been evaluated as a pharmacologic strategy to reduce postoperative sore throat yet. The investigator will explore how the analgesic and anti-inflammatory effects of ketorolac influence airway symptoms following general anesthesia with tracheal intubation. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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