Medical Induction of Labor Affecting Fetus Clinical Trial
Official title:
Titrated Oral Misoprostol Compared to Vaginal Dinoprostone for Induction of Labor: a Randomized Control Trial
To test the safety and efficacy of titrated oral misoprostol compared to vaginal dinoprostone for labor induction.
- There are many indications for induction of labor in the obstetric practice, of which
prolonged gestational age stands as the most common indication. It is well recognized
that with an unripe cervix, induction may be difficult and often unsuccessful. The use
of an agent to ripen the cervix prior to induction is acceptable in the modern
practice.
- Misoprostol, a prostaglandin E1 analogue, is the most interesting alternative to
Dinoprostone because of its effectiveness, low cost, and temperature stability. It
ripens the cervix by inducing regular uterine contractions. However, it is associated
with several adverse effects especially uterine hyperstimulation, which is painful and
may result in fetal compromise.
- Testing the efficacy and safety of titrated oral misoprostol versus vaginal
dinoprostone may develop a new safe and effective method for labor induction.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02508402 -
Effect Of Intra-muscular Administration of Dexamethasone in Induction of Labour
|
Phase 4 |