Becker's Muscular Dystrophy (BMD) Clinical Trial
Official title:
Pilot Study to Assess the Efficacy of L-Citrulline and Metformin in Adults With Becker's Muscular Dystrophy
The purpose of the study is to compare the effects of L-citrulline and metformin and their combination therapy on muscle function and force in patients with Becker muscular dystrophy (BMD).
This is a single center, not-randomized open study. The study medication consists of
L-citrulline and metformin administered orally; 5g citrulline and 500mg metformin tablets
will be given 3 times daily.
Half of the patients will be treated with metformin during the first 6 weeks of the study.
The other patients will receive initially L-citrulline for 6 weeks, before all patients will
be treated with the combination therapy (metformin and L-citrulline) for another 6 week
period.
The study lasts 12 weeks and includes the screening visit and 3 further visits at baseline,
week 6 and week 12.
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Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment