Dexamethasone-induced Hiccup in Chemotherapy Clinical Trial
Official title:
Antiemetic Corticosteroid Rotation From Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated With Chemotherapy: A Randomized, Single-Blind, Crossover Phase III Trial
Verified date | April 2017 |
Source | Chung-Ang University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.
Status | Completed |
Enrollment | 65 |
Est. completion date | July 31, 2016 |
Est. primary completion date | June 30, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - all solid cancer patients on chemotherapy - age >18 years - received dexamethasone as an antiemetic Exclusion Criteria: - brain metastases - hiccups before dexamethasone administration - uncontrolled diabetes mellitus - uncontrolled esophagitis or peptic ulcer |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Gyeongsang National University Hospital | Chiram-dong, Jinju-si | Gyeongsangnam-do |
Korea, Republic of | Chungang University Hospital | Dongjak-gu | Seoul |
Lead Sponsor | Collaborator |
---|---|
Chung-Ang University | Dong-A University Hospital, Gyeongsang National University Hospital, Samsung Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The intensities of hiccups | Clinically assessed every cycles(2-4weeks). The intensities of hiccups were assessed using a NRS. | 2 months | |
Secondary | The intensities of emesis | CLinically assessed every cycles (2-4weeks) The intensities of emesis were assessed using a NRS. | 2 months |