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ACTH in Progressive Forms of MS

Secondary Progressive Multiple Sclerosis Clinical Trial

Official title:
Treatment of Progressive Forms of Multiple Sclerosis With Pulsed ACTH (Acthar Gel)

Clinical Trial Summary

This is a phase II, randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety, tolerability, and efficacy of adrenocorticotropic hormone (ACTH, Acthar gel) administered as a pulsed regimen consisting of injections on three consecutive days per month in patients with progressive forms of Multiple Sclerosis (MS). Patients will be randomly assigned to either an ACTH arm or a placebo arm. The main hypotheses are that 1) pulsed ACTH will be safe and well-tolerated, and 2) pulsed ACTH will slow progression of clinical and paraclinical measures of MS progression compared to placebo.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Multiple Sclerosis
  • Multiple Sclerosis, Chronic Progressive
  • Primary Progressive Multiple Sclerosis
  • Progressive Relapsing Multiple Sclerosis
  • Sclerosis
  • Secondary Progressive Multiple Sclerosis
Clinical Trial Details
NCT number NCT01950234
Study type Interventional
Source University of Minnesota
Contact
Status Terminated
Phase Phase 2
Start date April 17, 2014
Completion date December 31, 2022
View Details
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