Transient Tachypnea of the Newborn Clinical Trial
Official title:
Inhaled Corticosteroids for the Treatment of Transient Tachypnea of the Newborn in Infants Born at >34 Weeks Gestation: A Prospective, Randomized, Double Blind, Placebo Controlled Study.
Transient Tachypnea of the Newborn (TTN) is a common respiratory disorder affecting late
preterm and term babies caused by lung edema resulting from delayed absorption of fetal
alveolar lung fluid.
The investigators hypothesize that ENAC expression will be up-regulated as a result of
administration of corticosteroids. This effect will lead to enhanced absorption of fetal
lung fluid finally treating TTN. The aim of our study will be to evaluate whether inhaled
corticosteroids reduce respiratory distress and morbidity in late preterm and term neonates
presenting with TTN.
The primary outcome measure will be the assessment of respiratory distress reflected by TTN clinical score in neonates presenting with TTN and treated with inhaled corticosteroids compared to placebo. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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