Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A

Charcot-Marie-Tooth Type 1A Neuropathy Clinical Trial

— CCA1  

Official title:

Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01750710
• Other study ID #: CHU-0128
• Status: Completed
• Start date: December 2012
• Est. completion date: April 28, 2016

Study information

• Verified date: October 2019
• Source: University Hospital, Clermont-Ferrand
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This exploratory cross-sectional study proposes, firstly, to objectify in a population of Charcot-Marie-Tooth disease type 1A (CMT 1A)if there is a correlation between the recording of electrical parameters and upper limb muscle strength of the thigh and in a second step, to seek a relationship between the measured parameters.

Description:

Patients suffering from CMT 1A neuropathy will be invited to go through a series of tests such as:

• Electromyography

• Isokinetic test

• Podiatric assessment

• Functional evaluations: Hand dexterity, limbs muscles strength

• Quality of life assessment with questionnaires

Recruitment information / eligibility

• Status: Completed
• Enrollment: 37
• Est. completion date: April 28, 2016
• Est. primary completion date: April 28, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients older than 18 years

• Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2)

• Listening and written French

• Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome.

• Strength of the quadriceps superior to 2/5 MMT MRC

Exclusion Criteria:

• Presence of other neurological comorbidity

• Presence of coronary artery disease unstabilized

• Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy.

• Gait trouble of other origin

• Patients unable to give their consent.

• Intellectual deficit that does not allow to comply with tests

Related Conditions & MeSH terms

• Charcot-Marie-Tooth Disease
• Charcot-Marie-Tooth Type 1A Neuropathy
• Hereditary Sensory and Motor Neuropathy
• Nerve Compression Syndromes
• Peripheral Nervous System Diseases
• Tooth Diseases

Locations

Country	Name	City	State
France	CHU Clermont-Ferrand	Clermont-Ferrand

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Clermont-Ferrand

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	axonal loss		at day 1
Secondary	Muscle strength		at day 1
Secondary	Functional scores		at day 1
Secondary	Hand testing		at day 1
Secondary	spatial and temporal parameters of walking		at day 1
Secondary	Barometric stabilometric podo-static scores		at day 1
Secondary	Quality of life		at day 1
Secondary	Fatigue		at day 1
Secondary	Depression		at day 1