Poisoning by Paraquat With Undetermined Intent Clinical Trial
Official title:
The Efficacy and Safety of Continuous Venovenous Hemofiltration in Patients With Severe Acute Paraquat Poisoning
Paraquat poisoning is characterized by multiple organ failure and pulmonary fibrosis with respiratory failure. Accumulating evidence suggested that continuous venovenous hemofiltration (CVVH) had a beneficial role in the treatment of multiple organ dysfunction. The investigators hypothesized that CVVH might restore multiple organ function and reduce the high mortality rate of paraquat poisoning. To confirm it, an prospective clinical study would be carried out.
Paraquat (1,1 '-dimethyl-4,4'-bipyridylium dichloride) is widely used as a herbicide.
Accidental or intentional ingestion of paraquat is common in many developing countries such
as China, Sri Lanka and Korea because of easy access. The high mortality rate of paraquat is
due to its high toxicity and the lack of effective treatments. Thus, the paraquat poisoning
becomes one of major medical problem in the developing countries.
Paraquat poisoning is also one of major causes of death among young patients with acute
poisoning in China. It is characterized by multiple organ failure and pulmonary fibrosis
with respiratory failure. A growing body of evidence suggested that continuous venovenous
hemofiltration (CVVH) had a great beneficial role in the treatment of multiple organ
dysfunctions. We hypothesized that CVVH might reduce the high mortality rate of paraquat
poisoning via restoring the multiorgan function, such as acute hepatic lesion, acute kidney
injury, acute lung injury and acute pancreatic injury. We expect to enroll 100 patients from
our hospital within 1 week after oral intake of paraquat. All patients were divided into
Group 1 and Group 2. Group 1 were treated with a standardized therapeutic regimen including
stomach lavage, emergency haemoperfusion and drugs. Group 2 were accepted with standardized
treatment plus CVVH. The aim of this prospective clinical study was to evaluate the safety
and efficacy of CVVH for the treatment of patients with paraquat poisoning. The survival
rate, clinical manifestations and clinical parameters between these two groups were
compared.
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Observational Model: Cohort, Time Perspective: Prospective