Clinical Pregnancy After Single Embryo Transfer Clinical Trial
Official title:
Time Lapse Embryo Monitoring Versus Standard Embryo Monitoring for Selection for Single Blastocyst Transfer
Verified date | January 2018 |
Source | Kaali Institute IVF Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
A multiple pregnancy is an undesired outcome of assisted reproduction. Current embryo selection technologies are inefficient in identifying the embryo with the highest implantation potential. Time lapse (TL) embryo monitoring provides additional information about embryo development and therefore may aid embryo selection. The investigators aim is to study whether TL monitoring is superior to traditional embryo observation when a single blastocyst is selected for transfer (ET).
Status | Terminated |
Enrollment | 161 |
Est. completion date | April 2015 |
Est. primary completion date | April 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 36 Years |
Eligibility |
Inclusion Criteria: - Age < 36 yrs - baseline FSH <10 IU/l - regular 25-35 day cycles - less than 2 previous failed IVF cycles - intact uterus - an indication for IVF - BMI <18- <30 kg/m2 - acceptance of single embryo transfer Exclusion Criteria: - PCOS - Sperm obtained by surgical extraction - chromosome abnormality - Presence of hydrosalpinx - stage III/IV endometriosis - Less than 3 good quality day 3 embryos - only one good quality day 5 embryos - lack of consent |
Country | Name | City | State |
---|---|---|---|
Hungary | Forgacs Intezet | Budapest | |
Hungary | Kaali Institute IVF Center | Budapest |
Lead Sponsor | Collaborator |
---|---|
Kaali Institute IVF Center | Forgacs Intezet Budapest, Hungary |
Hungary,
Meseguer M, Herrero J, Tejera A, Hilligsøe KM, Ramsing NB, Remohí J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod. 2011 Oct;26(10):2658-71. doi: 10.1093/humrep/der256. Epub 2011 Aug 9. — View Citation
Pribenszky C, Losonczi E, Molnár M, Lang Z, Mátyás S, Rajczy K, Molnár K, Kovács P, Nagy P, Conceicao J, Vajta G. Prediction of in-vitro developmental competence of early cleavage-stage mouse embryos with compact time-lapse equipment. Reprod Biomed Online. 2010 Mar;20(3):371-9. doi: 10.1016/j.rbmo.2009.12.007. Epub 2010 Jan 25. — View Citation
Pribenszky C, Mátyás S, Kovács P, Losonczi E, Zádori J, Vajta G. Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring. Reprod Biomed Online. 2010 Oct;21(4):533-6. doi: 10.1016/j.rbmo.2010.04.015. Epub 2010 Apr 24. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Time Lapse Score | a score based on 8 observations by time lapse monitoring | the time lapse score is assessed on the day of embryo transfer (day 5 after the egg retrieval) | |
Other | Perinatal Outcome | gestational age at delivery, birth weight, | perinatal outcome assessed after delivery | |
Primary | Pregnancy Rate | rise in beta HCG 12-14 days after transfer | 12-14 days after transfer | |
Secondary | Live Birth | live birth after 24 weeks gestation | delivery after 24 weeks |