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Clinical Trial Summary

In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and estrogen levels fall sharply at this time. During medical abortion the endometrial shedding is sometimes ineffective causing an incomplete abortion which may cause prolonged bleeding or require surgical intervention. In medical abortion a progesterone antagonist is used as treatment but the estrogen levels are not targeted. The investigators wish to explore whether addition of letrozole or trilostane which target estrogen levels can lead to a more effective shedding of the endometrial lining.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms

  • Medical Abortion, Complete or Unspecified, Without Complication

NCT number NCT01615211
Study type Interventional
Source Karolinska Institutet
Contact
Status Terminated
Phase Phase 2
Start date May 2012
Completion date October 2013

See also
  Status Clinical Trial Phase
Recruiting NCT04160221 - Second Trimester Medical Abortion N/A
Completed NCT03207880 - Piloting Use of Multi-Level Pregnancy Tests in Remote Abortion Services N/A