Effects of Glucose-fructose Drinks During Training on Lactate Transport

Normal Physiology on Healthy Subjects Clinical Trial

— LactEx  

Official title:

Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01610986
• Other study ID #: 251/11
• Status: Completed
• Phase: N/A
• First received: May 23, 2012
• Last updated: June 3, 2014
• Start date: May 2012
• Est. completion date: March 2014

Study information

• Verified date: June 2014
• Source: University of Lausanne
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Description:

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: March 2014
• Est. primary completion date: March 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy

• age between 18 and 30 years

• sedentary

• BMI between 19 and 25

• blood pressure lower than 140/90 mmHg

Exclusion Criteria:

• smoking

• consumption of more than 10g alcohol per day

• cardiovascular history

• electrographic abnormalities at rest

• consumption of more than one can of soda per day or more than 60g sugars per day

• any current drug treatment

• consumption of drugs or illicit substances

• diabetes mellitus

• vegetarian

• food intolerance

• blood donation or participation to another study <3 months before study inclusion

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Normal Physiology on Healthy Subjects

Intervention

Dietary Supplement:
• Glucose-fructose
0.8 g/h glucose and 0.5 g/h fructose during training
• Water
Only water intake during training

Locations

Country	Name	City	State
Switzerland	University of Lausanne	Lausanne	Vaud

Sponsors (2)

Lead Sponsor	Collaborator
University of Lausanne	Centre Hospitalier Universitaire Vaudois

Country where clinical trial is conducted

Switzerland, 

References & Publications (1)

Lecoultre V, Benoit R, Carrel G, Schutz Y, Millet GP, Tappy L, Schneiter P. Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose. Am J Clin Nutr. 2010 Nov;92(5):1071-9. doi: 10.3945/ajcn.2010.29566. Epub 2010 Sep 8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in lactate transport	Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)	At baseline (before training) and after the 3-week training protocol	No
Secondary	Change in muscle monocarboxylate transporters (MCTs) expression and protein content	MCTs expression (mRNA) and protein content after muscle biopsy	At baseline (before training) and after the 3-week training protocol	No