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NCT01585389 Clinical Trial

Studying Gene Expression and Location in Samples From Patients With Brain Tumors

Brain and Central Nervous System Tumors Clinical Trial

Official title:
Expression and Subcellular Localization of NEIL3 in Tumors

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01585389
Other study ID # ABTR12B3
Secondary ID COG-ABTR12B3ABTR
Status Completed
Phase N/A
First received April 24, 2012
Last updated May 17, 2016
Start date April 2012

Study information
Verified date May 2016
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.

PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.

Description:

OBJECTIVES:

- To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.

OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date
Est. primary completion date May 2016
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility DISEASE CHARACTERISTICS:

- Tissue microarrays (TMA) samples from the Biopathology Core

- Samples from patients diagnosed with brain tumors

- Progenitor, or blast, cell origin

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Genetic:
• gene expression analysis

• genetic linkage analysis

• microarray analysis

Other:
• immunohistochemistry staining method

• laboratory biomarker analysis

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome
Type Measure Description Time frame Safety issue
Primary Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation No
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