Compare Blood Age for Transfusion Clinical Trial
Official title:
Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital
In resolving lactic acidosis among children with severe malarial anemia, there is no difference between those transfused with blood of longer storage compared to shorter storage age
Objective of the study is to evaluate the effect of blood storage age on resolution of
lactic acidosis in children with severe malarial anemia.
Methods:
Children aged 6 - 59 months admitted to ACU with Severe Malarial Anemia (Hb <5g/dl) and
Lactic Acidosis (blood lactate >5 mmol /l), will be randomly assigned to receive either
blood of shorter storage age (<10 days) or longer storage age (21 -35 days) by gravity
infusion as is the routine practice. 37 patients will be enrolled in each study arm.
Physiological measurements namely blood lactate, oxygen saturation, Hemoglobin, Blood
pressure, respiratory rate and pulse rate will be taken at baseline, during and after
transfusion. The two groups will be compared. The primary outcome variable will be the
proportion of children whose lactic acidosis resolves after 4 hrs of transfusion. 24hr
mortality will be our secondary outcome.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment