Effect of Dietary Sodium Intake on Vascular Endothelium

Postural Tachycardia Syndrome (POTS) Clinical Trial

Official title: A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium

Status Completed

Clinical Trial Summary

The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet. The investigators will compare patients with postural orthostatic tachycardia (POTS) to healthy control subjects.

Clinical Trial Description

The study will involve a crossover design in which each subject will be assessed (as below) while on a very low-sodium (10 mEq/day) diet compared with a very high-sodium diet. These acute dietary interventions will be part of the parent study ("Dietary Salt in Postural Tachcyardia Syndrome" funded by R01 HL102387) for 4-5 days at the time of the study. Dietary success will be assessed using a 24h urine for sodium and creatinine as a part of the parent study.

Blood will be drawn and collected in a fasting state for future assay and analysis of the following tests:

• Glucose, Insulin (glucose impairment, insulin resistance)

• Fasting lipid profile

• C-Reactive Protein (hsCRP) (inflammatory state)

• Inflammatory cytokines (inflammatory state)

• aliquots (future analysis)

Pulsitile Arterial Tonometry (PAT) Protocol Calf Blood Flow in Reactive Hyperemia (CBF-RH) - venous occlusion plethysmography Evaluation of Forearm-Mediated Dilation ;

Related Conditions & MeSH terms

• Postural Orthostatic Tachycardia Syndrome
• Postural Tachycardia Syndrome (POTS)
• Tachycardia

• NCT number: NCT01550315
• Study type: Interventional
• Source: Vanderbilt University Medical Center
• Status: Completed
• Phase: N/A
• Start date: April 2012
• Completion date: September 2021