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Clinical Trial Summary

The overall objective of the proposed research is to test the hypothesis that Near-infrared Light-emitting Diode (NIR-LED) therapy will stimulate mitochondrial function, attenuate oxidative stress, and improve cell survival and vision in subjects with Leber's Hereditary Optic Neuropathy (LHON).


Clinical Trial Description

To determine the effects of short term (3 month) near-infrared light NIR-LED therapy on anatomic and functional abnormalities of LHON as assessed by a wide variety of ophthalmologic tests, including visual acuity, optical coherence tomography, pattern electroretinography (pERG) N95 retinal ganglion cell peak, fERG-PhNR (flash ERG - Photopic Negative Response), and fundus photography. ;


Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01389817
Study type Interventional
Source Medical College of Wisconsin
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date July 2011
Completion date May 2013

See also
  Status Clinical Trial Phase
Completed NCT02771379 - Post Authorisation Safety Study With Raxone in LHON Patients
Completed NCT02774005 - Study to Assess the Efficacy and Safety of Raxone in LHON Patients Phase 4
Completed NCT02796274 - Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)
Recruiting NCT04912843 - Gene Therapy Clinical Trial for the Treatment Of Leber's HereDitary Optic Neuropathy Phase 2/Phase 3
Completed NCT05555784 - Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection