Relapsed and Refractory Acute Leukemia Clinical Trial
Official title:
Pilot Study of Hematopoietic Stem Cell Transplantation From Two Matched Sibling Donors in Treating Patients With Poor Prognosis Acute Leukemia and Advanced Lymphoproliferative Malignancies
Patients with active acute leukemia have dismal prognoses even with allogeneic
transplantation.Thus,new measures to enhance graft versus leukemia effect and reduce relapse
rates are needed.
Relapse risk after double umbilical cord transplantations have been shown to be
significantly lower compared to matched sibling and matched unrelated donor transplantations
due to better graft versus leukemia effect.
The investigators hypothesize, that concomitant transplantation from 2 matched siblings may
improve GVL effect and reduce relapse rate in patients with high risk acute leukemias and
other high risk hematological malignancies.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment