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NCT01340742 Clinical Trial

Remote Ischemic Preconditioning Before Abdominal Surgery

Perioperative/Postoperative Complications Clinical Trial

Official title:
Remote Ischemic Preconditioning Before Abdominal Surgery and the Prevalence of Perioperative Complications

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT01340742
Other study ID # R-10-132
Secondary ID 16811
Status Withdrawn
Phase N/A
First received
Last updated
Start date June 2010
Est. completion date June 2013

Study information
Verified date October 2023
Source Lawson Health Research Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Major abdominal surgeries are associated with perioperative cardiac morbidity of up to 10%. Ischemic preconditioning may have a protective effect. The purpose of this study is to find out remote ischemic conditioning by inflating a blood pressure cuff on the arm will have a protective effect.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date June 2013
Est. primary completion date December 2012
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Patients undergoing abdominal surgery:large bowel, pancreatic and hepatic surgery Exclusion Criteria: - Chronic inflammatory disease. - Glyburide use before surgery.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Remote Ischemic Pre-conditioning
Cuff placed on arm. Three 5- minute cycles of blood pressure cuff inflation: cuff is inflated to 200 mm Hg for 5 minutes followed by a 5-minute deflation (reperfusion.)
• Control
Cuff placed on arm uninflated for 30 minutes.

Locations
Country Name City State
Canada London Health Sciences Centre London Ontario

Sponsors (1)
Lead Sponsor Collaborator
Lawson Health Research Institute

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Cardiovascular Events: incidence of MI, TIA/stroke, death in both groups One week
Secondary Renal function deterioration in the first week after surgery Baseline Creatinine levels will be compared to the highest creatinine levels noted in the first 7 days of hospitalization One week
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