Post Operative Inflammatory Marker Levels Clinical Trial
Official title:
The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital: A Randomized Clinical Trial
. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult
patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect
on the levels of IL-6 & IL-1β pro inflammatory markers by 48 hours.
. Alternate Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult
patients undergoing elective surgery, in Mulago hospital, will have a reduction effect on
the levels of IL-6 & IL-1β pro inflammatory markers by 48 hours.
RESEARCH QUESTION Can 0.5mg/kg of Ketamine given preoperatively have an effect on the levels
of pro-inflammatory markers?
Primary specific Outcome: changes/deviations from baseline levels of IL- 6 pro-inflammatory
markers of after surgery at PACU, 24 and 48 hours.
Secondary specific Outcome: changes/deviations from baseline levels of IL-1β
pro-inflammatory markers of after surgery at PACU, 24 and 48 hours.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)