Microparticles (MP)Originating From Platelets, Endothelial Cells and Monocytes Clinical Trial
Official title:
Beta-thalassemia and Microparticles
The results will allow us to evaluate the role of MP in the thrombo-embolic risk observed in thalassemic patients and to underline a possible difference between TM and TI. The in vitro and in vivo study of MP in erythrocytes concentrates is a new approach to explore the consequence of transfusion in polytransfused patients. Finally, the identification of a possible relationship between the oxidative stress and the production of MP may lead to the development of specific therapeutical approaches
Microparticles (MP) are intact vesicles derived from cell membranes which arise mainly
through cell membrane activation processes and from apoptosis. MP originating from
platelets, endothelial cells and monocytes have been most extensively studied, though
similar particles can arise from red cells and granulocytes. The ability to form
microparticles is an essential part of physiological coagulation.However, MP may play an
important procoagulant role in several diseases including sickle cell disease, and
paroxysmal nocturnal haemoglobinuria (PNH).
Several studies reported the presence of MP in TI and their potential role in the
hypercoagulable state. The investigators propose in this study to investigate the presence
and origin of MP in TM patients.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label