Crohn Disease Located in Jejunum or Ileum Clinical Trial
Official title:
Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients
Patients with Crohn's disease (CD) have an increased risk of small bowel adenocarcinoma
(SBA). Long duration of CD is the main risk factor. SB dysplasia has been associated with
SBA in 20% of cases, always described in diseased sites. The progression to neoplasia and
natural history remains unknown but progression of inflammation to dysplasia and then to
adenocarcinoma is suspected.
As for surveillance recommendations for colorectal carcinoma in long standing inflammatory
colonic disease, endoscopic screening of SB could be proposed in CD patients with risk
factors of SBA. No study can be found in literature.
The investigators propose a multicenter exploratory open study on prospective cohort of CD
patients with high risk of dysplasia or cancer. The goal is evaluate the rate of dysplasia
and adenocarcinoma detected by enteroscopy with biopsies in a high risk CD population
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic