Articular Cartilage Defects of Knee Clinical Trial
Official title:
An Investigator-sponsored Trial for Observation of the Result After Chondron (Autologous Chondrocytes) Treatment
This investigator-sponsored trial attempts to evaluate the effectiveness of Chondron transplantation by tracking subjects who had the Chondron implantation to observe effectiveness.
| Status | Completed |
| Enrollment | 127 |
| Est. completion date | November 2009 |
| Est. primary completion date | August 2009 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 15 Years to 65 Years |
| Eligibility |
- Inclusion Criteria: 1. Adult males and females aged between 15 and 65 2. Patients with a partial cartilaginous defect in the ankle joint confirmed arthroscopically or visually 3. Patients with misalignment between tibia and talus of the ankle joint, lateral ankle instability, and a bony defect in the cartilaginous defect or who had a correction simultaneously or in advance 4. Patients whose surrounding cartilage is normal 5. Subjects who consented to the clinical trial or on whose behalf a person with parental rights consented to the clinical trial - Exclusion Criteria: 1. Patients hypersensitive to bovine protein 2. Patients hypersensitive to antibiotics like gentamicin 3. Patients with inflammatory arthritis, such as rheumatoid arthritis and gouty arthritis 4. Patients with arthritis associated with autoimmune diseases 5. Patients who are pregnant, nursing a baby or likely to get pregnant 6. Patients with other diseases including tumors except for cartilaginous defects of joints 7. Patients with an anamnesis within the past two years, such as radiation treatment and chemotherapy 8. Diabetics (however, patients who were normal in the blood glucose test and have no complication due to diabetes will be excluded if the doctor says Chondron can be administered to them) 9. Patients with infections who are taking antibiotics and antimicrobial agents 10. Patients who are treated with adrenal cortical hormones 11. Patients whom the investigators find to be unfit for this clinical trial, such as mental patients |
Observational Model: Case-Only, Time Perspective: Retrospective
| Country | Name | City | State |
|---|---|---|---|
| Korea, Republic of | Sewon Cellontech | Sungdong-ku | Seoul |
| Lead Sponsor | Collaborator |
|---|---|
| Sewon Cellontech Co., Ltd. |
Korea, Republic of,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Change of KSS(Knee Society Score)-A,B | pre-operation, post -operation 4month, post-operation 12month, over post-operation 24month. | No | |
| Secondary | Additional treatment related to autologous chondrocyte implantation | post -operation 4month, post-operation 12month, over post-operation 24month. | No | |
| Secondary | Satisfaction of patients | post -operation 4month, post-operation 12month, over post-operation 24month. | No |