Recurrent Respiratory Papillomatosis Clinical Trial
Official title:
A Pilot Study to Evaluate the Effects of Antiangiogenic Factor as an Adjunct Treatment After Photoangiolysis in Patients With Bilateral Recurrent Respiratory Papillomatosis of the Vocal Fold
This phase I single center open labeled study is planned to assess the safety and tolerability of bevacizumab for treating patients with bilateral Recurrent Respiratory Papillomatosis (RRP). Approximately 20 patients will receive bevacizumab directly injected into the vocal folds. Patients who enroll in the protocol will be injected with bevacizumab in one vocal fold that represents the more diseased of the two folds. A sham injection with saline will be administered to the other vocal fold as the control. This therapy will be administered once every 6 ± 1 week for 6 months, with the same vocal fold selected for the initial treatment always getting the drug injection. The investigator will also treat lesions by laser photoangiolysis of both vocal folds using the 532 nm potassium-titanyl-phosphate (KTP) laser.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT02854761 -
Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP)
|
Phase 1 | |
Terminated |
NCT00747461 -
Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD")
|
Phase 4 | |
Completed |
NCT00038714 -
A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis
|
Phase 2 | |
Completed |
NCT00205374 -
Use of Cidofovir for Recurrent Respiratory Papillomatosis
|
Phase 4 | |
Active, not recruiting |
NCT04724980 -
Adjuvant PRGN-2012 in Adult Patients With Recurrent Respiratory Papillomatosis
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT04645602 -
Lenvatinib and Pembrolizumab Combination Therapy In HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal, and/or Pulmonary Involvement
|
Phase 2 | |
Recruiting |
NCT01793168 -
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
|
||
Withdrawn |
NCT01058317 -
Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis
|
Phase 2/Phase 3 | |
Withdrawn |
NCT00829608 -
Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis
|
Phase 0 | |
Completed |
NCT00550914 -
Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP
|
N/A | |
Not yet recruiting |
NCT01995721 -
4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children
|
Phase 3 | |
Completed |
NCT02217358 -
Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions
|
N/A | |
Completed |
NCT00571701 -
Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis
|
Phase 2 | |
Recruiting |
NCT02555800 -
Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis
|
Phase 2 | |
Completed |
NCT03707587 -
M7824 in People With Recurrent Respiratory Papillomatosis
|
Phase 2 | |
Completed |
NCT02859454 -
Avelumab for People With Recurrent Respiratory Papillomatosis
|
Phase 2 | |
Active, not recruiting |
NCT02632344 -
Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients
|
Phase 2 | |
Completed |
NCT02592902 -
Recurrent Respiratory Papillomatosis and Extraesophageal Reflux
|
N/A | |
Recruiting |
NCT06412172 -
The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
|
||
Recruiting |
NCT03465280 -
Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP)
|