Systemic Inflammatory Response Syndrome Clinical Trial
Official title:
INFLACOR (INFLA-mmation A-fter C-ardiac O-pe-R-ation) - Use of Selected Genetic Variants, Cytokines, and Physiologic Parameters in the Prognosis of Postoperative Complications in Patients Undergoing Cardiopulmonary Bypass Cardiac Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary bypass.
Identified so far predictors of mortality and/or morbidity in patients who undergo heart
surgery with cardiopulmonary bypass (CPB), used in previous risk prediction models
(EUROSCORE, CABDEAL, Cleveland), will be compared with new candidate variables:
1. anamnestic: recent tooth extractions, chronic inflammatory diseases, specific drug use;
2. biochemical: C-reacting protein, interleukin-6, tumor necrosing factor alpha;
3. genetical: single nucleotide polymorphisms of 10 genes associated with inflammatory
response; and
4. clinical from the 1. postoperative day: systemic inflammatory response syndrome,
APACHE-III score;
against their predictive capability of selected clinical phenotypes of inflammatory response
occuring after surgery, beginning from day 2. after surgery.
;
Observational Model: Cohort, Time Perspective: Prospective
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