Brain and Central Nervous System Tumors Clinical Trial
Official title:
Diagnostic and Prognostic Markers in Low-Grade Gliomas
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.
PURPOSE: This research study is looking at tissue and blood samples from patients with
low-grade glioma.
OBJECTIVES:
- Evaluate the diagnostic and prognostic relevance of alterations of specific chromosomes
and chromosomal regions including 7, 9p, 10p, 10q, 13q, 17p, 17q, 19q, 22q, X, and Y,
using PCR analysis of microsatellite repeats and FISH.
- Evaluate the diagnostic and prognostic relevance of DNA ploidy by flow cytometric
analysis; compare with ploidy determination by FISH.
- Assess the diagnostic and prognostic relevance of various markers of cellular
proliferation and cellular function including flow cytometric determination of
%S-phase, %G2M, and immunohistochemical evaluation of PCNA, Ki-67, and p53.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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