Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial
Official title:
Molecular and Genetic Markers in the Local-regional Management of Patients Undergoing Radiation Therapy
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at molecular markers and genetic markers in patients
undergoing radiation therapy for cancer.
OBJECTIVES:
Primary
- Determine local-regional control in patients undergoing radiation therapy for cancer,
as a function of expression of specific molecular/genetic markers.
Secondary
- Determine complications of radiation therapy for patients undergoing radiation therapy
for cancer.
OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining
and other molecular/genetic study methods to detect markers, including p53, cyclin D1,
HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on
local-regional relapse.
;
Observational Model: Case Control, Time Perspective: Retrospective
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