Multiple Myeloma and Plasma Cell Neoplasm Clinical Trial
Official title:
Proposal for Combining ECOG Myeloma Trial SNP Data
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that may occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This laboratory study is looking at DNA samples from patients with multiple
myeloma.
OBJECTIVES:
- Determine whether there is an increased frequency of 1 or more polymorphic alleles that
are associated with clinical endpoints using custom myeloma single nucleotide
polymorphism (SNP) chip analysis of banked DNA samples from patients with multiple
myeloma.
- Determine SNPs associated with toxicities caused, not by variations in tumor cell
genetics, but by individual genetic variations affecting drug activation, distribution,
metabolism, and export (ADME).
- Determine SNPs associated with response, influenced by the same ADME.
- Determine SNPs associated with bone disease (as a variable) among patients with
multiple myeloma.
- Determine SNPs associated with epidemiology (i.e., risk factors for the development of
multiple myeloma).
OUTLINE: This is a retrospective, multicenter study.
Banked DNA samples are analyzed using a custom single nucleotide polymorphism (SNP) chip to
assess approximately 3,590 SNPs from 1,061 genes that are associated with myeloma growth and
response.
PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.
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