Brain and Central Nervous System Tumors Clinical Trial
Official title:
Optimizing EGFR Inhibitor-Based Therapies for GBM
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
predict how patients will respond to treatment.
PURPOSE: This laboratory study is looking at tissue samples from patients with glioblastoma
multiforme to identify biomarkers that may improve the selection of patients for epidermal
growth factor receptor inhibitor therapies.
OBJECTIVES:
Primary
- Identify molecular characteristics that predict for overall survival and
progression-free survival of patients treated with erlotinib hydrochloride,
temozolomide, and radiotherapy on clinical trial NCCTG-N0177.
Secondary
- Identify molecular characteristics that predict for overall survival and
progression-free survival of patients treated with gefitinib after radiotherapy on
clinical trial NCCTG-N0074.
OUTLINE: This is a multicenter study.
Tissue samples from patients enrolled on clinical trials NCCTG-N0177 or NCCTG-N0074 are
analyzed by microarray analysis and immunohistochemistry for biological markers predicting
progression-free survival and overall survival. Biological markers include epidermal growth
factor expression, vIII mutant p53 gene, P-AKT, p7056k, S6, 4EBP1, STAT-3, PLC-g, Erk, ErbB2,
ErbB3, ErbB4, platelet-derived growth factor receptor, IGF1R, interleukin-6, FADD, and MGMT.
PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.
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