Non-Small Cell Lung Cancer (NSCLC) Clinical Trial
Official title:
0516 GCC: Stereotactic Body Radiation Therapy As A Boost After Definitive Treatment With Concurrent Chemoradiation In Patients With Non-Small Cell Lung Cancer
SBRT to deliver a boost dose to residual primary tumor after definitive doses of standard
EBRT have been delivered concurrently with chemotherapy.
Serum levels of TGF-Beta1 and correlation with SBRT toxicity.
This protocol is designed to use stereotactic body radiation therapy (SBRT) to deliver a
boost dose to residual primary tumor after definitive doses of standard external beam
radiation have been delivered concurrently with chemotherapy. It is designed to determine the
toxicity profile(side effects) in the context of dose escalation of stereotactic body
radiation therapy (SBRT) after definitive therapy with concurrent chemoradiation and to
define the maximum tolerated dose.
Serum levels of TGF-Beta1 have been demonstrated to correlate with the incidence of the
radiation toxicity, pneumonitis in patients treated with standard external beam radiation.
This study will serially follow TGF-Beta1 levels in patients to see if the same correlation
exists with SBRT toxicity.
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