Vorinostat, Bortezomib, and Doxorubicin Hydrochloride Liposome in Treating Patients With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma and Plasma Cell Neoplasm Clinical Trial

Official title:

A Phase 1 Dose Escalation Study of Bortezomib (Velcade®), Pegylated Liposomal Doxorubicin (Doxil®), and Vorinostat (Suberoylanilide Hydromaxic Acid, Saha, Zolinzatm) in Patients With Relapse/Refractory Multiple Myeloma

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00744354
• Other study ID #: LCCC 0715
• Secondary ID: 08-1073
• Status: Terminated
• Phase: Phase 1
• First received: August 29, 2008
• Last updated: January 16, 2018
• Start date: October 2008
• Est. completion date: April 2015

Study information

• Verified date: January 2018
• Source: UNC Lineberger Comprehensive Cancer Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Vorinostat and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Bortezomib may also stop the growth of multiple myeloma by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving doxorubicin hydrochloride liposome together with vorinostat and bortezomib may kill more cancer cells.

PURPOSE: This phase I trial is studying the side effects and best dose of vorinostat and to see how well it works when given together with bortezomib and doxorubicin hydrochloride liposome in treating patients with relapsed or refractory multiple myeloma.

Description:

OBJECTIVES:

Primary

• To determine the maximum tolerated dose of vorinostat when added to the standard regimen of bortezomib and pegylated liposomal doxorubicin hydrochloride in patients with relapsed or refractory multiple myeloma.

• To identify the dose-limiting toxicities of this regimen in these patients.

Secondary

• To gain preliminary evidence of antitumor activity of this regimen in these patients.

• To assess the degree of proteasome inhibition achieved with this regimen in these patients.

• To evaluate the accumulation of acetylated alpha-tubulin after treatment with vorinostat.

• To evaluate overall survival, time to progression, and progression-free survival of patients treated with this regimen.

OUTLINE: This is a multicenter, dose escalation study of vorinostat.

Patients receive oral vorinostat once daily on days 1,2; 4,5; 8, 9; 11, 12; bortezomib IV on days 1, 4, 8, and 11, and pegylated liposomal doxorubicin hydrochloride IV on day 4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Blood samples are collected periodically for proteasome inhibition assays and acetylated alpha-tubulin studies.

After completion of study treatment, patients are followed at 1 and 3 months.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 32
• Est. completion date: April 2015
• Est. primary completion date: December 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

DISEASE CHARACTERISTICS:

• Diagnosis of multiple myeloma

• Relapsed or refractory disease

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2

• Life expectancy = 3 months

• ANC = 1.0 x 10^9/L (no granulocyte growth factor support, e.g., G-CSF or GM-CSF allowed)

• Platelet count = 100 x 10^9/L (erythropoietin allowed, no platelet or RBC transfusion within the past 2 weeks)

• Hemoglobin = 8 g/dL (erythropoietin allowed, no platelet or RBC transfusion within the past 2 weeks)

• Creatinine clearance = 30 mL/min

• AST or ALT = 2.5 times upper limit of normal (ULN)

• Total bilirubin = 1.5 times ULN

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 3 months after completion of study treatment

• LVEF = 45% by MUGA or ECHO

• Symptomatic neuropathy < grade 2

• No known history of HIV

• No active or serious infection, medical or psychiatric illness that would preclude study participation

• No active hepatitis B or C infection

• No other prior or concurrent malignancy except for adequately treated basal cell or squamous cell carcinoma of the skin, in situ malignancy, low-risk prostate cancer after curative therapy, or other cancer for which the patient has been disease-free for = 3 years

• No history of hypersensitivity reaction to bortezomib or any of its components (boron, mannitol), vorinostat, doxorubicin hydrochloride, or any of the components of PLD

• No serum potassium = 3.0 or serum magnesium = 1.6 that cannot be corrected with supplementation are excluded

• Patients must have adequate cardiovascular function, defined by all of the following:

• No EKG evidence of active, clinically significant conduction system abnormalities

• No EKG evidence of QTc prolongation > grade 2

• NOTE: Any EKG abnormality at screening has to be documented by the investigator as not medically significant.

PRIOR CONCURRENT THERAPY:

• No limit to number of prior treatment regimens

• At least 30 days since prior therapy and recovered

• At least 3 months since prior autologous stem cell transplantation and recovered

• Prior allogeneic stem cell or bone marrow transplantation allowed provided the following criteria are met:

• More than 1 year since transplantation

• No longer receiving immunosuppressive therapy or treatment for graft-versus-host disease (GVHD) prophylaxis

• No active GVHD

• No active, uncontrolled infections

• No major surgery within the past 3 weeks

• No prior anthracycline dose > 360 mg/m^2 for doxorubicin hydrochloride (including pegylated liposomal doxorubicin hydrochloride [PLD]) or 720 mg/m^2 for epirubicin hydrochloride

• No prior or concurrent histone deacetylase inhibitor (e.g., valproic acid)

• No concurrent filgrastim (G-CSF) or sargramostim (GM-CSF) during course 1

• No other concurrent investigational or anticancer agent

Related Conditions & MeSH terms

• Multiple Myeloma
• Multiple Myeloma and Plasma Cell Neoplasm
• Neoplasms, Plasma Cell
• Plasmacytoma

Intervention

Drug:
• bortezomib
Intravenous Push 1.3 mg/m2 Days 1, 4, 8, and 11
• pegylated liposomal doxorubicin hydrochloride
Intravenous infusion, 30mg/m2, Day 4, each cycle
• vorinostat
Oral, 300mg, Days 1, 2, 4, 5, 8, 9, 11, 12, every cycle.

Locations

Country	Name	City	State
United States	Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill	Chapel Hill	North Carolina
United States	Duke Comprehensive Cancer Center	Durham	North Carolina
United States	Mount Sinai Medical Center	New York	New York
United States	Wake Forest University Comprehensive Cancer Center	Winston-Salem	North Carolina

Sponsors (4)

Lead Sponsor	Collaborator
UNC Lineberger Comprehensive Cancer Center	Merck Sharp & Dohme Corp., Millennium Pharmaceuticals, Inc., Ortho Biotech, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum tolerated dose of vorinostat		4 years
Secondary	Overall response rate		5 years
Secondary	Duration of response		5 years

External Links

•   Web address for UNC Lineberger Comprehensive Cancer Center