Sexual Dysfunction, Physiological Clinical Trial
Official title:
A Phase II Study of Vaginal Testosterone Cream vs. the ESTRING for Vaginal Dryness or Decreased Libido in Early Breast Cancer Patients Treated With Aromatase Inhibitors
The purpose of this clinical research study is to determine whether the ESTRING or a special preparation of a testosterone cream inserted vaginally are safe for use in breast cancer patients. This study will also evaluate if either of these treatments can improve symptoms of vaginal dryness or decreased sexual interest that are related to your treatment for breast cancer.
There is a growing body of scientific literature to suggest that sexual functioning is one of the most distressing problems experienced by breast cancer survivors. Vaginal dryness, dyspareunia (pain during sexual intercourse), and decreased libido are common complaints among breast cancer patients. With increasing use of aromatase inhibitors which are associated with a higher rate of vaginal dryness than tamoxifen, these problems are becoming even more prominent. This study will evaluate the safety and tolerability of the ESTRING and 1% testosterone cream administered vaginally as treatments for vaginal dryness and/or decreased libido in women receiving an aromatase inhibitor for early stage breast cancer. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01021670 -
An Observational Study of Men With Premature Ejaculation Who Are Treated With Dapoxetine Hydrochloride or Alternate Care Defined as Any Treatment Other Than Dapoxetine Hydrochloride
|
Phase 4 | |
| Completed |
NCT00324948 -
Topical Alprostadil for Female Sexual Arousal Disorder
|
Phase 2 | |
| Recruiting |
NCT02624648 -
Effects of Lepidium Meyenii Walp on Sexual Function in Postmenopausal Women
|
Phase 1 | |
| Completed |
NCT05692960 -
Women's Interventions for Sexual Health: WISH
|
N/A | |
| Completed |
NCT01188720 -
Sexual Health on Antidepressants Through Physical Exercise
|
N/A | |
| Completed |
NCT00692419 -
Pain, Sexual Dysfunction, and Depression in Hemodialysis Patients
|
N/A | |
| Completed |
NCT01063881 -
The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy
|
Phase 3 | |
| Completed |
NCT00451165 -
Bowel, Urinary and Sexual Function After Laparoscopic Colorectal Surgery
|
N/A | |
| Recruiting |
NCT04604951 -
Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury
|
N/A | |
| Recruiting |
NCT04512287 -
PRP for Treatment of Peyronie's Disease
|
Phase 2 | |
| Completed |
NCT02381912 -
Sexual Function in Patients Suspected of Non-muscle Invasive Bladder Cancer
|
N/A | |
| Completed |
NCT00443248 -
Vaginal Heat Wash-out (HWO) in 4 Groups of Women (Pre- and Postmenopausal With and Without Female Sexual Arousal Disorder (FSAD)).
|
Phase 1 | |
| Completed |
NCT00443027 -
Effect Of Menstrual Cycle On Vaginal Blood Flow In Pre-Menopausal Healthy Women.
|
Phase 1 | |
| Completed |
NCT03241524 -
Consistency of Questionnaires to Evaluating Sexual Functions in Young Healthy Women
|
N/A | |
| Terminated |
NCT03018106 -
Ospemifene vs. Conjugated Estrogens in the Treatment of Postmenopausal Sexual Dysfunction
|
Phase 4 | |
| Completed |
NCT04364841 -
Body Image and Sexuality After Bariatric Surgery
|
||
| Completed |
NCT03592121 -
Study to Investigate the Effect of AB-101 in Breast Cancer Survivors
|
Early Phase 1 | |
| Completed |
NCT00482664 -
The Efficacy, Safety And Toleration Of CP-866,087 In Pre-Menopausal Women With Female Sexual Arousal Disorder.
|
Phase 2 | |
| Recruiting |
NCT05456919 -
Quality of Sexual Function in BRCA Mutated Women
|
||
| Recruiting |
NCT06308614 -
Estetrol for the Treatment of Female Sexual Arousal Disorder in Postmenopausal Women
|
Phase 2 |