Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD)

Attention Deficit Disorder With Hyperactivity Clinical Trial

— TDA/H  

Official title:

Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00684931
• Other study ID #: CHUBX 2007/21
• Status: Terminated
• Phase: N/A
• First received: May 22, 2008
• Last updated: June 22, 2009
• Start date: February 2008
• Est. completion date: July 2008

Study information

• Verified date: June 2009
• Source: University Hospital, Bordeaux
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Direction Générale de la Santé
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

Description:

ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 19
• Est. completion date: July 2008
• Est. primary completion date: February 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

Patient with ADHD :

• Diagnosis of ADHD

• 18 - 35 years old

Healthy volunteer :

• 18 - 35 years old

• no ADHD diagnosed

Exclusion Criteria:

• Associated neurological or psychiatric pathologies

• Pregnant woman

• MRI counter indication

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Attention Deficit Disorder With Hyperactivity
• Hyperkinesis

Intervention

Other:
• Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Locations

Country	Name	City	State
France	Charles Perrens Hospital	Bordeaux
France	University Hospital Bordeaux	Bordeaux

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Bordeaux

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fractional anisotropy coefficient if fronto-cerebello-frontal loops.		visite 1	No