Proliferative Diabetic Retinopathy Clinical Trial
Official title:
Pattern Scan Laser System vs Regular Photocoagulation System: Changes in Electroretinograms and Contrast Sensitivity Post Treatment.
Verified date | May 2024 |
Source | Asociación para Evitar la Ceguera en México |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Laser photocoagulation has become the treatment of choice in PDR. Laser photocoagulation has become the treatment of choice in PDR. The aim is to destroy a substantial portion of the peripheral retina in order to reduce the angiogenic stimulus (decrease the difference between oxygen demand and the administration). Their effectiveness is determined by the extent of destruction of the retina (2.4).
Status | Terminated |
Enrollment | 8 |
Est. completion date | February 2008 |
Est. primary completion date | October 2007 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 25 Years to 95 Years |
Eligibility | Inclusion Criteria: - Patients older than 25 years, with a diagnosis of severe NPDR or PRD. - Good pupil mydriasis (minimum 5mm) With clear media - Patients without previous laser treatment or treatment with antiangiogenic drug. Exclusion Criteria: - Patients who do not accept informed consent. - Patients with clinical macular Edema before treatment. - Significant corneal opacity. - Patients with other eye diseases that interfere with the studies required for the monitoring of patients. - History of refractive surgery, glaucoma or ocular hypertension, intraocular inflammation, choroiditis multifocal, retinal detachment, optic neuropathy (4). - Patients with tractional retinal detachment due to abundant fibrovascular |
Country | Name | City | State |
---|---|---|---|
Mexico | Asociaciòn para Evitar la Ceguera en Mèxico | Mèxico | DF |
Lead Sponsor | Collaborator |
---|---|
Asociación para Evitar la Ceguera en México |
Mexico,
Blumenkranz MS, Yellachich D, Andersen DE, Wiltberger MW, Mordaunt D, Marcellino GR, Palanker D. Semiautomated patterned scanning laser for retinal photocoagulation. Retina. 2006 Mar;26(3):370-6. doi: 10.1097/00006982-200603000-00024. No abstract available. — View Citation
Greenstein VC, Chen H, Hood DC, Holopigian K, Seiple W, Carr RE. Retinal function in diabetic macular edema after focal laser photocoagulation. Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3655-64. — View Citation
Liang JC, Fishman GA, Huamonte FU, Anderson RJ. Comparative electroretinograms in argon laser and xenon arc panretinal photocoagulation. Br J Ophthalmol. 1983 Aug;67(8):520-5. doi: 10.1136/bjo.67.8.520. — View Citation
Nonaka A, Kiryu J, Tsujikawa A, Yamashiro K, Nishijima K, Kamizuru H, Ieki Y, Miyamoto K, Nishiwaki H, Honda Y, Ogura Y. Inflammatory response after scatter laser photocoagulation in nonphotocoagulated retina. Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1204-9. — View Citation
Perlman I, Gdal-On M, Miller B, Zonis S. Retinal function of the diabetic retina after argon laser photocoagulation assessed electroretinographically. Br J Ophthalmol. 1985 Apr;69(4):240-6. doi: 10.1136/bjo.69.4.240. — View Citation
Rema M, Sujatha P, Pradeepa R. Visual outcomes of pan-retinal photocoagulation in diabetic retinopathy at one-year follow-up and associated risk factors. Indian J Ophthalmol. 2005 Jun;53(2):93-9. doi: 10.4103/0301-4738.16171. — View Citation
Varano M, Parisi V, Tedeschi M, Sciamanna M, Gallinaro G, Capaldo N, Catalano S, Pascarella A. Macular function after PDT in myopic maculopathy: psychophysical and electrophysiological evaluation. Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1453-62. doi: 10.1167/iovs.04-0903. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in a wave amplitude | 12 weeks | ||
Primary | changes in b wave amplitude | 12 weeks | ||
Primary | changes in ERG implicit time | 12 weeks |
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