Neuropsychological Functioning Among Children With Tourret's Disorder and ADHD

Attention-Deficit/Hyperactivity Disorder Clinical Trial

Official title:

Neuropsychological Functioning, Symptomatology, and Social Adjustment Among Children With Tourret's Disorder, Attention-Deficit/Hyperactivity Disorder, and Comorbid Conditions.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00416091
• Other study ID #: 9561706006
• Secondary ID: NTUH96- S558
• Status: Completed
• Phase: N/A
• First received: December 22, 2006
• Last updated: November 12, 2012
• Start date: January 2007
• Est. completion date: December 2007

Study information

• Verified date: September 2008
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

Tourette's disorder (TD) is a childhood-onset neuropsychiatric disorder, manifesting motor and vocal tics with increased likelihood of comorbid with attention-deficit/hyperactivity disorder (ADHD) and other psychiatric disorders. Literature documents the comorbid condition with ADHD predicts an increased functional deficit among individuals with ADHD. The information about neuropsychological functioning among individuals with TD adn/or ADHD is little in Asian population. This study aims to validate the diagnoses of TD, ADHD, and TD comorbid ADHD by symptomatology, neuropsychological measures, and social adjustment. This is a case-control study with a sample of 30 subjects with TD, 60 with ADHD, 30 with TD+ADHD, and 60 controls aged from 6 to 18. All subjects will receive comprehensive assessment including standard psychiatric diagnostic interviews using (K-SADS-E), behavioral assessments (SNAP-IV, CPRS:R-S, CTRS:R-S, CBCL, YBOCS, YGTSS), social adjustment (SAICA, GCAS), parenting (PBI, APGAR) and neuropsychological assessment (CPT, CANTAB, WISC-III). We anticipate that this study will provide the primitive data to validate the TD and ADHD using neuropsychological and clinical measures.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: December 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 8 Years to 16 Years

Eligibility

Inclusion Criteria:

• patients aged 8-16 without the diagnosis of ADHD, and/or Tourette's disorder

• IQ > 80

• both children/adolescents and their parents consent to participate and have the ability to complete self-administered measures in this study

Exclusion Criteria:

• diagnosis of psychotic disorders, bipolar affective disorders, pervasive developmental disorder, seizure, or major physical disorders.

• in addition, control subjects will be excluded from the control group if have a history of the following condition as defined by DSM-IV: ADHD, ODD, or CD in addition to the above exclusion criteria.

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

• Attention Deficit Disorder with Hyperactivity
• Attention-Deficit/Hyperactivity Disorder
• Disease
• Hyperkinesis
• Tourette Disorder
• Tourette Syndrome

Locations

Country	Name	City	State
Taiwan	Department of Psychiatry, National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Barkley RA (1997), Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121: 65-94 Channon S, Pratt P, Robertson MM (2003b), Executive function, memory, and learning in Tourette's disorder. Neuropsychology 17: 247-54 Gau SS, Soong WT, Chiu YN, Tsai WC (2006a), Psychometric properties of the Chinese version of the Conners' Teacher and Parent Rating Scales-Revised Short Form. Journal of Attention Disorders. 9: 648-659 Gau SSF, Shen HY, Soong WT, Gau CS (2006b), An open-label, randomized, active controlled equivalent trial of OROS methylphenidate in children with attention-deficit/hyperactivity disorder in Taiwan. Journal of Child and Adolescent Psychopharmacology 16 (in press) Kurlan R, Whitmore D, Irvine C, McDermott MP, Como PG (1994), Tourette's disorder in a special education population: a pilot study involving a single school district. Neurology 44: 699-702