Brain and Central Nervous System Tumors Clinical Trial
Official title:
NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy Using [F18] Fluorothymidine (FLT) As a Marker of Proliferation in Patients With Primary Brain Tumors
RATIONALE: Diagnostic procedures, such as positron emission tomography using fluorothymidine
F 18, may be effective in finding recurrent disease in patients with gliomas.
PURPOSE: This clinical trial is studying how well positron emission tomography using
fluorothymidine F 18 works in finding recurrent disease in patients with gliomas.
OBJECTIVES:
Primary
- Determine the safety of fluorothymidine F 18 for visual and dynamic brain tumor images
in patients with glial neoplasms.
- Determine, preliminarily, the efficacy of this drug.
Secondary
- Compare, preliminarily, the efficacy of this drug to fludeoxyglucose F 18 in
differentiating tumor recurrence from radiation necrosis.
- Determine the optimal time to image post injection of this drug.
OUTLINE: This is a pilot, nonrandomized study.
Patients receive fluorothymidine F 18 IV over 1 minute and then undergo positron emission
tomography (PET) scanning of the brain over 2 hours.
After completion of the PET scan, patients are followed for at least 1 month.
PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study.
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