Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation

Children With a Univentricular Heart Undergoing Surgery for Creation of a Fontan Circulation Clinical Trial

Official title: Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation

Status Completed

Clinical Trial Summary

Randomisation between postoperative administration of an ACE-inhibitor or not.

Clinical Trial Description

Children that are undergoing elective surgery for the creation of a Fontan circulation will be randomised to postoperative administration of an ACE-inhibitor or not.

Determination of aldosteron, renine and ADH in serum preoperatively and 1h, 12h and 5 days postoperatively. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Children With a Univentricular Heart Undergoing Surgery for Creation of a Fontan Circulation

• NCT number: NCT00263406
• Study type: Interventional
• Source: University Hospital, Ghent
• Status: Completed
• Phase: Phase 2
• Start date: December 2002
• Completion date: March 2007