Acute Uncomplicated Pyelonephritis Clinical Trial
Official title:
TREATMENT OF ACUTE UNCOMPLICATED PYELONEPHRITIS WITH SHORT COURSE LEVOFLOXACIN A Pilot Study
The purpose of the study is to compare the safety and effectiveness of the antibiotic levofloxacin by administering a higher dose of levofloxacin using a shorter course of therapy to treat patients with infections of their kidney.
The goal is to complete a pilot study of short course (5 days), high dose, levofloxacin
treatment for women with acute uncomplicated pyelonephritis. Specific study objectives
include:
1. To assess the efficacy and tolerability of levofloxacin 750 mg once daily for treatment
of acute uncomplicated pyelonephritis in 25 women.
2. To describe the population pharmacokinetics of levofloxacin 750 mg once daily in
treatment of young women with acute pyelonephritis.
3. To identify urine proteins associated with the inflammatory response of acute
pyelonephritis, and characterize the time course of resolution of these proteins
following initiation of treatment.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01390623 -
Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women
|
Phase 4 |